Blundell, Tom L.: search on Z-Library

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1

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

Pires, Douglas E. V., Blundell, Tom L., Ascher, David B.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 648 KB

english, 2015

2

ChemInform Abstract: Structure, Antiferromagnetism and Superconductivity of the Layered Iron Arsenide NaFeAs.

Dinah R. Parker, Michael J. Pitcher, Peter J. Baker, Isabel Franke, Tom Lancaster, Stephen J. Blundell, Simon J. Clarke

Journal:

Year:

2009

File:

PDF, 17 KB

2009

3

Hotspots API: A Python Package for the Detection of Small Molecule Binding Hotspots and Application to Structure-Based Drug Design.

Curran, Peter Richard, Radoux, Chris, Smilova, Mihaela D., Sykes, Richard, Higueruelo, Alicia, Bradley, Anthony, Marsden, Brian D., Spring, David R., Blundell, Tom L., Leach, Andrew R., Pitt, William

Journal:

Journal of Chemical Information and Modeling

Year:

2020

Language:

english

File:

PDF, 2.23 MB

english, 2020

4

Keynote review: Structural biology and drug discovery

Miles Congreve, Christopher W. Murray, Tom L. Blundell

Journal:

Drug Discovery Today

Year:

2005

Language:

english

File:

PDF, 238 KB

english, 2005

5

Progress in biophysics and molecular biology: A brief history of the journal

Noble, Denis, Blundell, Tom L., Kohl, Peter

Journal:

Progress in Biophysics and Molecular Biology

Year:

2018

Language:

english

File:

PDF, 254 KB

english, 2018

6

Magnetic order in the purely organic quasi-one-dimensional ferromagnet 2-benzimidazolyl nitronyl nitroxide

Sugano, Tadashi, Blundell, Stephen, Lancaster, Tom, Pratt, Francis, Mori, Hatsumi

Journal:

Physical Review B

Year:

2010

Language:

english

File:

PDF, 376 KB

english, 2010

7

Probing Hot Spots at Protein−Ligand Binding Sites: A Fragment-Based Approach Using Biophysical Methods

Ciulli, Alessio, Williams, Glyn, Smith, Alison G., Blundell, Tom L., Abell, Chris

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 274 KB

english, 2006

8

Insights into DNA recombination from the structure of a RAD51–BRCA2 complex

Yu, David S., Lo, Thomas, Anand, Shubha, Lee, MiYoung, Blundell, Tom L., Venkitaraman, Ashok R., Pellegrini, Luca

Journal:

Year:

2002

Language:

english

File:

PDF, 469 KB

english, 2002

9

Protein–protein interactions as druggable targets: recent technological advances

Higueruelo, Alicia P, Jubb, Harry, Blundell, Tom L

Journal:

Current Opinion in Pharmacology

Year:

2013

Language:

english

File:

PDF, 711 KB

english, 2013

10

Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining

Ochi, Takashi, Sibanda, Bancinyane Lynn, Wu, Qian, Chirgadze, Dimitri Y., Bolanos-Garcia, Victor M., Blundell, Tom L.

Journal:

Journal of Nucleic Acids

Year:

2010

Language:

english

File:

PDF, 8.83 MB

english, 2010

11

pyDock: Electrostatics and desolvation for effective scoring of rigid-body protein–protein docking

Tammy Man-Kuang Cheng, Tom L. Blundell, Juan Fernandez-Recio

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 436 KB

english, 2007

12

Gender diversity in sport leadership: an investigation of United States of America National Governing Bodies of Sport

Gaston, Lindsey, Blundell, Milly, Fletcher, Tom

Journal:

Managing Sport and Leisure

Year:

2020

File:

PDF, 1.29 MB

2020

13

Dissection of DNA double-strand-break repair using novel single-molecule forceps

Wang, Jing L., Duboc, Camille, Wu, Qian, Ochi, Takashi, Liang, Shikang, Tsutakawa, Susan E., Lees-Miller, Susan P., Nadal, Marc, Tainer, John A., Blundell, Tom L., Strick, Terence R.

Journal:

Nature Structural and Molecular Biology

Year:

2018

Language:

english

File:

PDF, 1.96 MB

english, 2018

14

Comparative Protein Modelling by Satisfaction of Spatial Restraints

Andrej Šali, Tom L. Blundell

Journal:

Journal of Molecular Biology

Year:

1993

File:

PDF, 2.24 MB

1993

15

The British antibiotic and silver-impregnated catheters for ventriculoperitoneal shunts multi-centre randomised controlled trial (the BASICS trial): study protocol

Jenkinson, Michael D, Gamble, Carrol, Hartley, John C, Hickey, Helen, Hughes, Dyfrig, Blundell, Michaela, Griffiths, Michael J, Solomon, Tom, Mallucci, Conor L

Journal:

Year:

2014

Language:

english

File:

PDF, 645 KB

english, 2014

16

Structural biology in fragment-based drug design

Christopher W Murray, Tom L Blundell

Journal:

Current Opinion in Structural Biology

Year:

2010

Language:

english

File:

PDF, 989 KB

english, 2010

17

HIGH-THROUGHPUT CRYSTALLOGRAPHY FOR LEAD DISCOVERY IN DRUG DESIGN

Blundell, Tom L., Jhoti, Harren, Abell, Chris

Journal:

Nature Reviews Drug Discovery

Year:

2002

Language:

english

File:

PDF, 491 KB

english, 2002

18

Structural biology and the design of new therapeutics: from HIV and cancer to mycobacterial infections

Thomas, Sherine E., Mendes, Vitor, Kim, So Yeon, Malhotra, Sony, Ochoa-Montaño, Bernardo, Blaszczyk, Michal, Blundell, Tom L.

Journal:

Journal of Molecular Biology

Year:

2017

Language:

english

File:

PDF, 1.25 MB

english, 2017

19

Fragment-based design of Mycobacterium tuberculosis InhA inhibitors

Sabbah, Mohamad, Mendes, Vitor, Vistal, Robert G, Dias, David M, ZÃ¡horszkÃ¡, Monika, MikuÅ¡ovÃ¡, KatarÃna, KordulÃ¡kovÃ¡, Jana, Coyne, Anthony G, Blundell, Tom L., Abell, Chris

Journal:

Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 2.14 MB

english, 2020

20

[Advances in Protein Chemistry] Volume 26 || Insulin: The Structure in the Crystal and its Reflection in Chemistry and Biology by

Year:

1972

Language:

english

File:

PDF, 6.40 MB

english, 1972

21

Identifying Interactions that Determine Fragment Binding at Protein Hotspots

Radoux, Chris John, Olsson, Tjelvar S. G., Pitt, William Ross, Groom, Colin R., Blundell, Tom L.

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 2.61 MB

english, 2016

22

Chimeric Glycosyltransferases for the Generation of Hybrid Glycopeptides

Andrew W. Truman, Marcio V.B. Dias, Shu Wu, Tom L. Blundell, Fanglu Huang, Jonathan B. Spencer

Journal:

Chemistry & Biology

Year:

2009

Language:

english

File:

PDF, 953 KB

english, 2009

23

Molecular anatomy: Phyletic relationships derived from three-dimensional structures of proteins

Mark S. Johnson, Michael J. Sutcliffe, Tom L. Blundell

Journal:

Journal of Molecular Evolution

Year:

1990

Language:

english

File:

PDF, 1.61 MB

english, 1990

24

Metalloproteinase super–families and drug design

Blundell, Tom L

Journal:

Natural Structural Biology

Year:

1994

File:

PDF, 267 KB

1994

25

Knowledge-based protein modelling and design

Tom BLUNDELL, Devon CARNEY, Stephen GARDNER, Fiona HAYES, Brendan HOWLIN, Tim HUBBARD, John OVERINGTON, Diljeet Athwal SINGH, Bancinyane Lynn SIBANDA, Michael SUTCLIFFE

Journal:

Year:

1988

Language:

english

File:

PDF, 781 KB

english, 1988

26

Use of Amino Acid Environment-dependent Substitution Tables and Conformational Propensities in Structure Prediction from Aligned Sequences of Homologous Proteins. II. Secondary Structures

Hiroshi Wako, Tom L. Blundell

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 1.10 MB

1994

27

Eye-lens proteins: The three-dimensional structure of β-crystallin predicted from monomeric γ-crystallin

Graeme Wistow, Christine Slingsby, Tom Blundell, Huub Driessen, Wilfried De Jong, Hans Bloemendal

Journal:

Year:

1981

Language:

english

File:

PDF, 622 KB

english, 1981

28

High-throughput X-ray crystallography for drug discovery

Tom L Blundell, S Patel

Journal:

Current Opinion in Pharmacology

Year:

2004

Language:

english

File:

PDF, 312 KB

english, 2004

29

1.15 Å Crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family

Nicholas J. Harmer, Jeremy M. Sivak, Enrique Amaya, Tom L. Blundell

Journal:

Year:

2005

Language:

english

File:

PDF, 482 KB

english, 2005

30

Towards a Resolution of the Stoichiometry of the Fibroblast Growth Factor (FGF)–FGF Receptor–Heparin Complex

Nicholas J Harmer, Leopold L Ilag, Barbara Mulloy, Luca Pellegrini, Carol V Robinson, Tom L Blundell

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 1.40 MB

english, 2004

31

Sequence analyses and comparative modeling of fly and worm fibroblast growth factor receptors indicate that the determinants for FGF and heparin binding are retained in evolution

H.G Nagendra, Adrian E Harrington, Nicholas J Harmer, Luca Pellegrini, Tom L Blundell, David F Burke

Journal:

Year:

2001

Language:

english

File:

PDF, 1.89 MB

english, 2001

32

Experimental and Theoretical Electron Density Analysis of Copper Pyrazine Nitrate Quasi-Low-Dimensional Quantum Magnets

Dos Santos, Leonardo H. R., Lanza, Arianna, Barton, Alyssa M., Brambleby, Jamie, Blackmore, William J. A., Goddard, Paul A., Xiao, Fan, Williams, Robert C., Lancaster, Tom, Pratt, Francis L., Blundell

Journal:

Journal of the American Chemical Society

Year:

2016

Language:

english

File:

PDF, 6.05 MB

english, 2016

33

A fragment-based approach to targeting inosine-5´-monophosphate dehydrogenase (IMPDH) from Mycobacterium tuberculosis

Trapero, Ana, Pacitto, Angela, Singh, Vinayak, Sabbah, Mohamad, Coyne, Anthony G, Mizrahi, Valerie, Blundell, Tom L., Ascher, David B., Abell, Chris

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.34 MB

english, 2018

34

Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach

Mugumbate, Grace, Mendes, Vitor, Blaszczyk, Michal, Sabbah, Mohamad, Papadatos, George, Lelievre, Joel, Ballell, Lluis, Barros, David, Abell, Chris, Blundell, Tom L., Overington, John P.

Journal:

Frontiers in Pharmacology

Year:

2017

Language:

english

File:

PDF, 2.18 MB

english, 2017

35

Arginine-deprivation–induced oxidative damage sterilizes Mycobacterium tuberculosis

Tiwari, Sangeeta, van Tonder, Andries J., Vilchèze, Catherine, Mendes, Vitor, Thomas, Sherine E., Malek, Adel, Chen, Bing, Chen, Mei, Kim, John, Blundell, Tom L., Parkhill, Julian, Weinrick, Brian, Be

Journal:

Proceedings of the National Academy of Sciences

Year:

2018

Language:

english

File:

PDF, 1.52 MB

english, 2018

36

The molecular organization of human cGMP specific phosphodiesterase 6 (PDE6): Structural implications of somatic mutations in cancer and retinitis pigmentosa

Maryam, Arooma, Vedithi, Sundeep Chaitanya, Khalid, Rana Rehan, Alsulami, Ali F., Torres, Pedro Henrique Monteiro, Siddiqi, Abdul Rauf, Blundell, Tom L.

Journal:

Computational and Structural Biotechnology Journal

Year:

2019

Language:

english

File:

PDF, 14.57 MB

english, 2019

37

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools

Sebastian-Perez, Victor, García-Rubia, Alfonso, Seif el-Din, Sayed H., Sabra, Abdel-Nasser A., El-Lakkany, Naglaa M., William, Samia, Blundell, Tom L., Maes, Louis, Martinez, Ana, Campillo, Nuria E.,

Journal:

Journal of Enzyme Inhibition and Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 2.83 MB

english, 2020

38

A second front against AIDS

Blundell, Tom, Pearl, Laurence

Journal:

Year:

1989

File:

PDF, 240 KB

1989

39

Symposium 1: Structure and engineering of proteins: New developments

Hartmut Michel, Mark S. Johnson, John Overington, Andrej Šali, Zangyang Zhu, Dan Donnelly, Pam Thomas, Alasdair McCleod, Richard Goold, Chris Topham, Tom L. Blundell, Tom Alber, David P. Goldenberg, P

Journal:

Analytical and Bioanalytical Chemistry

Year:

1990

Language:

english

File:

PDF, 295 KB

english, 1990

40

Efficient Restraints for Protein–Protein Docking by Comparison of Observed Amino Acid Substitution Patterns with those Predicted from Local Environment

Vijayalakshmi Chelliah, Tom L. Blundell, Juan Fernández-Recio

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 851 KB

english, 2006

41

10.1016/S0968-0004(76)80141-7

Journal:

Trends in Biochemical Sciences

Year:

1976

Language:

english

File:

PDF, 245 KB

english, 1976

42

A structure-guided fragment-based approach for the discovery of allosteric inhibitors targeting the lipophilic binding site of transcription factor EthR

Surade, Sachin, Ty, Nancy, Hengrung, Narin, Lechartier, Benoit, Cole, Stewart T., Abell, Chris, Blundell, Tom L.

Journal:

Biochemical Journal

Year:

2014

Language:

english

File:

PDF, 2.24 MB

english, 2014

43

Control of the Competition between a Magnetic Phase and a Superconducting Phase in Cobalt-Doped and Nickel-Doped NaFeAs Using Electron Count

Parker, Dinah R., Smith, Matthew J. P., Lancaster, Tom, Steele, Andrew J., Franke, Isabel, Baker, Peter J., Pratt, Francis L., Pitcher, Michael J., Blundell, Stephen J., Clarke, Simon J.

Journal:

Physical Review Letters

Year:

2010

Language:

english

File:

PDF, 952 KB

english, 2010

44

In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity

Pires, Douglas E. V., Chen, Jing, Blundell, Tom L., Ascher, David B.

Journal:

Scientific Reports

Year:

2016

Language:

english

File:

PDF, 1.58 MB

english, 2016

45

Decoding the similarities and differences among mycobacterial species

Malhotra, Sony, Vedithi, Sundeep Chaitanya, Blundell, Tom L., Yang, Ruifu

Journal:

PLoS Neglected Tropical Diseases

Year:

2017

Language:

english

File:

PDF, 3.45 MB

english, 2017

46

Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors

Sabbah, Mohamad, Mendes, Vitor, Vistal, Robert G., Dias, David M. G., ZÃ¡horszkÃ¡, Monika, MikuÅ¡ovÃ¡, KatarÃna, KordulÃ¡kovÃ¡, Jana, Coyne, Anthony G., Blundell, Tom L., Abell, Chris

Journal:

Journal of Medicinal Chemistry

Year:

2020

File:

PDF, 337 KB

2020

47

Structural aspects of the functional modules in human protein kinase-Cα deduced from comparative analyses

Srinivasan, N., Bax, Ben, Blundell, Tom L., Parker, Peter J.

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1996

Language:

english

File:

PDF, 1.80 MB

english, 1996

48

An automatic method involving cluster analysis of secondary structures for the identification of domains in proteins

R. Sowdhamini, Tom L. Blundell

Journal:

Protein Science

Year:

1995

Language:

english

File:

PDF, 8.74 MB

english, 1995

49

Structural biology and drug discovery for protein–protein interactions

Harry Jubb, Alicia P. Higueruelo, Anja Winter, Tom L. Blundell

Journal:

Trends in Pharmacological Sciences

Year:

2012

Language:

english

File:

PDF, 1.76 MB

english, 2012

50

Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins

Ben Bax, Tom L Blundell, Judith Murray-Rust, Neil Q McDonald

Journal:

Year:

1997

Language:

english

File:

PDF, 1.94 MB

english, 1997

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